Ranexa is used to treat adults with angina that keeps coming back, also known as chronic angina. It is not for use during an acute (emergency) attack of angina. Ranolazine works by improving blood flow to help the heart work more efficiently. Ranexa may be used with other medicines that are used for heart problems and blood pressure control.
Take Ranexa exactly as prescribed by your doctor. Follow all directions on your prescription label. The recommended does is 500 mg orally twice daily. Ranexa may be taken with or without food. Do not crush, chew, or break an extended-release tablet. Swallow it whole.
Limit the amount of grapefruit products you eat or drink as grapefruit can cause your blood levels of Ranexa to increase. Ranexa can cause dizziness, lightheadedness, or fainting. If you have these symptoms, do not drive a car, use machinery or do anything that needs you to be alert.
You should not take Ranexa if you are allergic to ranolazine, or if you have cirrhosis of the liver. To make sure Ranexa is safe for you, tell your doctor if you have a heart rhythm disorder, kidney disease, a personal or family history of long QT syndrome.
Possible side effect
The most common side effects are dizziness, headache, constipation and nausea. Ranexa may cause serious side effects such as changes in the electrical activity of your heart called QT prolongation and kidney failure in people who already have severe kidney problems.
Do not take Ranexa if you use drugs for fungus infection: ketoconazole (Nizoral), itraconazole (Sporanox, Onmel); for infection: clarithromycin (Biaxin); for depression: nefazodone; for HIV: nelfinavir (Viracept), ritonavir (Norvir), lopinavir and ritonavir (Kaletra), indinavir (Crixivan), saquinavir (Invirase); for tuberculosis (TB): rifampin (Rifadin), rifabutin (Mycobutin), rifapentine (Priftin); for seizures: phenobarbital, phenytoin (Phenytek, Dilantin, Dilantin), carbamazepine (Tegretol); the herbal supplement St. John's wort.
If you miss a dose of Ranexa, wait to take the next dose at your regular time. Do not take more than 1 dose at a time.
Overdose can cause nausea, vomiting, numbness or tingling, dizziness, double vision, confusion and even fainting. If you think you have overdosed the medicine seek emergency medical help at once.
Store Ranexa at room temperature away from moisture and heat.
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